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GENETIC (DNA) TESTING:
Advances in Canine Genetic testing can now tell you whether your pet carries a gene mutation that can lead to a deadly bleeding disorder like Tye 3, von Willebrand disease. If you have a mixed breed dog, it can reveal your pet's mixed heritage. By knowing the parentage our Veterinarians can accurately determine the genetic diseases your pet at risk. As in human medicine, the potential exists for personalized medicine for veterinary patients in which medical care is tailored to the individual patient based on his or her genetics.
We are proud to announce the availability of genetic tesing at Summit Boulevard Animal Hospital for breed identification, parentage testing, phenotype trait testing such as coat color and gentic disease testing.
Why you need to do genetic disease testing? Knowing your pet has bleeding disorder like von Willebrand, our Veterinarians to pre treat your pet prior to any surgical procedure. This pre treating will help to prevent complications during and after surgery and help to save your pet's life and additional expense.
The following genetic tests are currently available.
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Disease |
Causative Gene |
Breeds Affected |
Inheritance Pattern |
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Arrhythmogenic right ventricular cardiomyopathy |
STRN |
Boxer |
Autosomal dominant incomplete penetrance |
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Canine leukocyte adhesion deficiency |
ITGB2 |
Irish setter |
Autosomal recessive |
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Canine multifocal retinopathy |
VMD2 |
Mastiff, Great Pyrenees, Coton de Tulear |
Autosomal recessive |
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Centronuclear myopathy |
PTPLA |
Labrador retriever |
Autosomal recessive |
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Cerebellar ataxia |
Not stated |
American Staffordshire terrier, American pit bull terrier |
Autosomal recessive |
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Cobalamin malabsorption |
Not stated |
Australian shepherd, giant schnauzer |
Not stated |
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Collie eye anomaly, choroidal hypoplasia |
NHEJ1 |
Australian shepherd, border collie, Lancashire heeler, rough collie, Shetland sheepdog, smooth collie |
Autosomal recessive |
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Cone degeneration |
CNGB3 |
German shorthaired pointer, Alaskan malamute |
Autosomal recessive |
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Cone-rod dystrophy 2 |
Not stated |
American pit bull terrier |
Autosomal recessive |
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Cone-rod dystrophy 3 |
ADAM9 |
Glen of Imaal terrier |
Autosomal recessive |
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Congenital hypothyroidism with goiter |
TPO |
Toy fox terrier |
Autosomal recessive |
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Congenital stationary night blindness |
REP65 |
Briard |
Autosomal recessive |
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Copper toxicosis |
COMMD1 |
Bedlington terrier |
Autosomal recessive |
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Cyclic neutropenia |
AP3B1 |
Collie |
Autosomal recessive |
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Cystinuria |
SLC3A1 |
Newfoundland, Labrador retriever |
Autosomal recessive |
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Degenerative myelopathy |
SOD1 |
To many to list (all breeds can be tested) |
Autosomal recessive |
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Dilated cardiomyopathy |
PDK4 |
Doberman pinscher |
Autosomal dominant |
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Dominant progressive retinal atropy |
RHO |
Old English mastiff, bullmastiff |
Autosomal dominant |
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Exercise-induced collapse |
DNM1 |
Labrador retriever, Boykin spaniel, Chesapeake Bay retriever, curly coated retriever, German wirehaired pointer, Pembroke Welsh corgi |
Autosomal recessive |
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Factor VII deficiency |
CFVII |
Beagle, Airedale terrier, Alaskan klee kai, giant schnauzer, Scottish deerhound |
Autosomal recessive |
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Familial nephropathy |
COL4A4 |
English cocker spaniel |
Autosomal recessive |
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Fucosidosis |
FUCA |
English springer spaniel |
Autosomal recessive |
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Glanzmann’s thombasthenia |
ITGA2B |
Otterhound, Great Pyrenees |
Autosomal recessive |
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Globoid cell leukodystrophy |
GALC |
Cairn terrier, West Highland white terrier |
Autosomal recessive |
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Glycogen storage disease type IIIa |
AGL |
Curly coated retriever |
Autosomal recessive |
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Hemophilia B |
F9 (coagulation factor IX) |
Bull terrier, Lhasa apso |
X-linked recessive |
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Hereditary nephritis |
COL4A5 |
Samoyed |
X-linked dominant |
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Hyperuricosuria |
SLC2A9 |
Dalmatian, black Russian terrier, beagle (all breeds can be tested) |
Autosomal recessive |
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Ichthyosis |
KRT10 |
Norfolk terrier, golden retriever |
Autosomal recessive |
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Juvenile hereditary/early onset cataracts |
HSF4 |
Boston terrier, Staffordshire bull terrier, French bulldog |
Autosomal recessive |
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Juvenile hereditary cataracts |
HSF4 |
Australian shepherd |
Autosomal dominant-incomplete penetrance |
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Juvenile dilated cardiomyopathy |
Unknown |
Portuguese water dog |
Autosomal recessive |
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L-2-hydroxyglutaric aciduria |
L2HGDH |
Staffordshire bull terrier |
Autosomal recessive |
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Leonberger polyneuropathy |
LPN1 |
Leonberger, Saint Bernard |
Not stated |
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Musladin-Lueke syndrome |
ADAMTSL2 |
Beagle |
Autosomal recessive |
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Mucopolysaccharidosis VII |
GUSB |
German shepherd |
Autosomal recessive |
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Mucopolysaccharidosis IIIB |
NAGLU |
Schipperke |
Autosomal recessive |
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Mucopolysaccharidosis VI |
ARSB |
Miniature pinscher |
Autosomal recessive |
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Multidrug sensitivity |
MDR1 |
Too many to list (all breeds can be tested) |
Autosomal recessive |
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Myotonia congenita |
CLC-1 |
Miniature schnauzer |
Autosomal recessive |
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Narcolepsy |
HCRTR2 |
Dachshund, Doberman pinscher, Labrador retriever |
Autosomal recessive |
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Neonatal encephalopathy |
ATF2 |
Standard poodle |
Autosomal recessive |
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Neuronal ceroid lipofuscinosis |
CTSD, TPP1, CLN5, ATP13A2 |
American bulldog, English setter, dachshund, border collie, Tibetan terrier |
Autosomal recessive |
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Phosphofructokinase deficiency |
M-PFK |
English springer spaniel, American and English cocker spaniel, whippet |
Autosomal recessive |
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Polyneuropathy |
NDRG1 |
Greyhound |
Autosomal recessive |
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Primary hyperparathyroidism |
Not stated |
Keeshond |
Autosomal dominant |
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Primary lens luxation |
ADAMTS17 |
Too many to list |
Autosomal recessive |
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Progressive retinal atrophy (RPGRIP1) |
RPGRIP1 |
Miniature longhaired dachshund |
Autosomal recessive-incomplete penetrance |
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Progressive retinal atrophy (PDEB) |
PDEB |
Cardigan Welsh corgi, Irish setter |
Autosomal recessive |
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Progressive retinal atrophy (PRCD) |
PRCD |
Too many to list |
Autosomal recessive |
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Progressive retinal atrophy (PDE6A) |
PDE6A |
Cardigan Welsh Corgi |
Autosomal recessive |
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Progressive retinal atrophy (PDE6B) |
PDE6B |
Irish setter, sloughi |
Autosomal recessive |
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Progressive retinal atrophy type A |
Not stated |
Miniature schnauzer |
Autosomal dominant-incomplete penetrance |
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Progressive retinal atrophy X-linked |
RPGR |
Samoyed, Siberian husky |
X-linked recessive |
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Pug dog encephalitis |
Unknown |
Pug |
Autosomal recessive |
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Pyruvate dehydrogenase phosphate deficiency |
PDP1 |
Clumber spaniel, Sussex spaniel |
Autosomal recessive |
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Pyruvate kinase deficiency |
R-PK |
West Highland white terrier, basenji, beagle, Cairn terrier, Laborador retriever, pug |
Autosomal recessive |
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Renal cystadenocarcinoma modular dermatofibrosis |
BHD |
German Shepherd |
Autosomal dominant |
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Retinal dysplasia/oculoskeletal dysplasia |
COL9A |
Labrador retriever (Col9A3), Samoyed (Col9A2) |
Autosomal recessive |
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Rod-Cone dysplasia type-2 |
RD3 |
Collie |
Autosomal recessive |
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Severe combined immunedeficiency |
IL-2RG |
Basset hound, Welsh corgi |
X-linked recessive |
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Thrombopathia |
RASGRP2 |
Basset hound |
Autosomal recessive |
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Von Willebrand disease type I |
vWF |
Bernese mountain dog, Cotton de Tulear, Doberman pinscher, Drentsche patrijshond, German pinscher, Kerry blue terrier, papillon, Pembroke Welsh corgi, poodle, stabyhoun |
Autosomal recessive with incomplete penetrance |
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Von Willebrand disease type II |
vWF |
Deutsch Drahthaar, German shorthaired pointer, German wirehaired pointer, German longhaired pointer, collie, pointer |
Autosomal recessive |
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Von Willebrand disease type III |
vWF |
Scottish terrier, Shetland sheepdog, kooikehondje |
Autosomal recessive |
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